Paula’s Choice put Hannah Waddingham at the center of its newest skincare launch on September 15. The Emmy-winning actor fronts the campaign for the brand’s Pro-Collagen Peptide Plumping Intensive Moisturizer, moving peptide terminology into a conventional celebrity beauty promotion (Paula’s Choice announcement).
The campaign sells familiarity as much as formulation. Waddingham gives the product a recognizable face, while phrases such as “Pro-Collagen” and “peptide-powered” supply the scientific register. Shoppers still need to separate the spokesperson, the brand’s test results and the wider research on topical peptides.
Three peptides, one finished formula
Paula’s Choice lists palmitoyl tripeptide-5, palmitoyl tetrapeptide-7 and palmitoyl hexapeptide-12 in the moisturizer’s three-peptide complex. The formula also contains red micro-algae extract and a lipid blend intended to limit moisture loss (Paula’s Choice).
The company says an independent clinical study involving 33 participants found visible plumping after four weeks. That number describes a test of the finished moisturizer. It does not establish that each peptide works on its own, nor does it support claims about injectable peptides or prescription treatment.
Recent consumer reporting has described topical peptide skincare as a gentler option for changes in firmness and texture, while also noting that peptide creams do not replace procedures or medical care (Mathrubhumi English). Our systematic review of cosmetic peptide evidence explains why studies on a branded formula should be judged separately from research on an isolated ingredient.
The same caution applies when shoppers recognize one peptide name from another product. For example, the new moisturizer’s published ingredient list does not include GHK-Cu. Evidence discussed in our guide to GHK-Cu and collagen remodeling cannot be transferred to this Paula’s Choice formula.
Celebrity reach changes the audience
Waddingham’s role matters because the campaign reaches people who may never search for a peptide study or visit an aesthetic clinic. It presents peptides as an ordinary part of a nightly skincare routine rather than an experimental wellness protocol.
That is a different type of celebrity story from Dana White’s public account of peptide use or the marketing questions raised by Kris Jenner’s peptide hair regimen. Waddingham is promoting a topical cosmetic with a disclosed ingredient list, not describing injections or an off-label medical protocol.
The distinction keeps the story useful. Celebrity attention can make an unfamiliar ingredient sound established before most shoppers have read the label. In this case, Paula’s Choice provides the three peptide names and a small product-level study. Buyers still have to decide whether that evidence justifies the moisturizer’s claims and price.

