Biochemical Storage Reference
Peptide Diluent Solubility & Thermal Stability Matrix
Evidence-based solvent recommendations, pH windows, and temperature degradation timelines across research peptides. Prevent peptide denaturation and precipitation.
BPC-157
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (15 AA) Recommended Reconstitution Diluent:
Bacteriostatic Water (0.9% Benzyl Alcohol) or Sterile Saline
Alternative: 0.6% Acetic Acid (optional for acetate salts) Degradation Timeline:
Reconstituted at 4°C (Refrigerated):30 - 45 days
Reconstituted at 22°C (Room Temp):48 - 72 hours
Lyophilized Powder at -20°C:24 - 36 months
Freeze-Thaw Tolerance:Poor (avoid repeated freeze-thaw cycles after reconstitution)
Light / UV Sensitivity:Moderate (store in amber vial or dark refrigeration)
Handling Protocol:Resilient pentadecapeptide. Direct water down the vial side. Swirl gently; avoid violent agitation or vortexing.
TB-500 (Thymosin Beta-4 Fragment)
Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (7 AA fragment) / Tβ4 (43 AA) Recommended Reconstitution Diluent:
Bacteriostatic Water (0.9% Benzyl Alcohol)
Alternative: Sterile Saline 0.9% Degradation Timeline:
Reconstituted at 4°C (Refrigerated):21 - 28 days
Reconstituted at 22°C (Room Temp):24 - 48 hours
Lyophilized Powder at -20°C:24 months
Freeze-Thaw Tolerance:Very Poor (actin-binding domains denature rapidly on freezing)
Light / UV Sensitivity:High (protect from UV/ambient light)
Handling Protocol:Extremely sensitive to mechanical shearing. Never shake or vortex. Allow powder to dissolve naturally over 5-10 minutes.
Tirzepatide
39 AA synthetic peptide with C20 fatty diacid moiety Recommended Reconstitution Diluent:
Bacteriostatic Water (0.9% Benzyl Alcohol)
Alternative: Bacteriostatic 0.9% Sodium Chloride Degradation Timeline:
Reconstituted at 4°C (Refrigerated):28 - 30 days
Reconstituted at 22°C (Room Temp):14 - 21 days (moderate stability)
Lyophilized Powder at -20°C:24 - 36 months
Freeze-Thaw Tolerance:Do not freeze once reconstituted (causes peptide fibrillation)
Light / UV Sensitivity:Moderate
Handling Protocol:C20 diacid chain self-associates. Reconstitute slowly; let settle for 10 minutes until completely clear before drawing.
Semaglutide
31 AA GLP-1 analog with C18 diacid spacer and Aib8 substitution Recommended Reconstitution Diluent:
Bacteriostatic Water (0.9% Benzyl Alcohol)
Alternative: Sterile Saline with preservative Degradation Timeline:
Reconstituted at 4°C (Refrigerated):30 - 56 days
Reconstituted at 22°C (Room Temp):28 days (commercial pen equivalent)
Lyophilized Powder at -20°C:36 months
Freeze-Thaw Tolerance:Do not freeze liquid solution
Light / UV Sensitivity:High (protect from direct sunlight)
Handling Protocol:Highly stable modified backbone resistant to DPP-4. Store refrigerated at 2°C - 8°C.
Retatrutide
39 AA triple agonist with branched fatty acid sidechain Recommended Reconstitution Diluent:
Bacteriostatic Water (0.9% Benzyl Alcohol)
Alternative: Sterile Water for Injection (single-use) Degradation Timeline:
Reconstituted at 4°C (Refrigerated):28 - 35 days
Reconstituted at 22°C (Room Temp):7 - 10 days
Lyophilized Powder at -20°C:24 months
Freeze-Thaw Tolerance:Poor
Light / UV Sensitivity:Moderate
Handling Protocol:Keep refrigerated. Inspect for clarity; discard if cloudy or precipitated.
Mod GRF 1-29 (CJC-1295 No DAC)
29 AA tetrasubstituted GHRH fragment Recommended Reconstitution Diluent:
Bacteriostatic Water (0.9% Benzyl Alcohol)
Alternative: Sterile Saline, 0.6% Acetic Acid Degradation Timeline:
Reconstituted at 4°C (Refrigerated):21 - 28 days
Reconstituted at 22°C (Room Temp):12 - 24 hours
Lyophilized Powder at -20°C:24 months
Freeze-Thaw Tolerance:Very Poor (rapid oxidation of Met27 and deamidation)
Light / UV Sensitivity:High
Handling Protocol:Prone to rapid oxidation. Keep strictly at 4°C after mixing. Avoid ambient air exposure.
CJC-1295 with DAC
Mod GRF 1-29 + (Maleimidopropionyl)-Lysine linker Recommended Reconstitution Diluent:
Bacteriostatic Water (0.9% Benzyl Alcohol)
Alternative: 0.6% Acetic Acid / Water Degradation Timeline:
Reconstituted at 4°C (Refrigerated):28 - 35 days
Reconstituted at 22°C (Room Temp):24 - 48 hours
Lyophilized Powder at -20°C:24 months
Freeze-Thaw Tolerance:Poor
Light / UV Sensitivity:High
Handling Protocol:Maleimide functional group binds serum albumin upon injection. Reconstitute gently without vigorous mixing.
Ipamorelin
Aib-His-D-2-Nal-D-Phe-Lys-NH2 (5 AA) Recommended Reconstitution Diluent:
Bacteriostatic Water (0.9% Benzyl Alcohol)
Alternative: Sterile Saline 0.9% Degradation Timeline:
Reconstituted at 4°C (Refrigerated):30 - 45 days
Reconstituted at 22°C (Room Temp):48 hours
Lyophilized Powder at -20°C:24 - 36 months
Freeze-Thaw Tolerance:Moderate
Light / UV Sensitivity:Moderate
Handling Protocol:Relatively stable pentapeptide. Compatible with CJC-1295 in pre-mixed blend vials if kept at 4°C.
GHK-Cu (Copper Tripeptide)
Gly-His-Lys:Cu2+ (3 AA chelate) Recommended Reconstitution Diluent:
Bacteriostatic Water or Sterile Water for Injection
Alternative: 0.9% Normal Saline, Deionized Water Degradation Timeline:
Reconstituted at 4°C (Refrigerated):30 - 60 days
Reconstituted at 22°C (Room Temp):7 - 14 days
Lyophilized Powder at -20°C:36 months
Freeze-Thaw Tolerance:Moderate
Light / UV Sensitivity:Very High (photoreduction of Cu2+ to Cu+)
Handling Protocol:Distinctive blue color. If solution turns clear, yellow, or greenish-brown, copper dissociation has occurred. Store strictly in darkness.
MOTS-c
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (16 AA) Recommended Reconstitution Diluent:
Bacteriostatic Water or Sterile Saline
Alternative: 0.6% Acetic Acid (if solubility is low) Degradation Timeline:
Reconstituted at 4°C (Refrigerated):14 - 21 days
Reconstituted at 22°C (Room Temp):12 - 24 hours
Lyophilized Powder at -20°C:24 months
Freeze-Thaw Tolerance:Extremely Poor (hydrophobic residues aggregate easily)
Light / UV Sensitivity:High
Handling Protocol:Hydrophobic sequence. If powder is slow to dissolve, let sit at 4°C for 20 minutes; do not heat or shake vigorously.
SS-31 (Elamipretide)
D-Arg-Dmt-Lys-Phe-NH2 (4 AA) Recommended Reconstitution Diluent:
Bacteriostatic Water (0.9% Benzyl Alcohol)
Alternative: Sterile Saline 0.9% Degradation Timeline:
Reconstituted at 4°C (Refrigerated):30 days
Reconstituted at 22°C (Room Temp):48 hours
Lyophilized Powder at -20°C:24 months
Freeze-Thaw Tolerance:Moderate
Light / UV Sensitivity:Moderate
Handling Protocol:Dmt residue is sensitive to strong oxidizers. Keep cold and shielded from direct sunlight.
Epitalon (Epithalon)
Ala-Glu-Asp-Gly (4 AA) Recommended Reconstitution Diluent:
Bacteriostatic Water (0.9% Benzyl Alcohol)
Alternative: Sterile Saline, Sterile Water Degradation Timeline:
Reconstituted at 4°C (Refrigerated):30 - 45 days
Reconstituted at 22°C (Room Temp):3 - 5 days
Lyophilized Powder at -20°C:36 months
Freeze-Thaw Tolerance:Good (short linear tetrapeptide)
Light / UV Sensitivity:Low
Handling Protocol:Short tetrapeptide with excellent stability compared to large multi-chain peptides.
Semax
Met-Glu-His-Phe-Pro-Gly-Pro (7 AA) Recommended Reconstitution Diluent:
Bacteriostatic Water or Sterile Deionized Water (Intranasal)
Alternative: 0.1% Methylparaben solution Degradation Timeline:
Reconstituted at 4°C (Refrigerated):30 days
Reconstituted at 22°C (Room Temp):7 days
Lyophilized Powder at -20°C:24 months
Freeze-Thaw Tolerance:Poor
Light / UV Sensitivity:High
Handling Protocol:If preparing for nasal spray delivery, avoid benzyl alcohol if mucous membrane irritation occurs; use sterile saline or methylparaben.
Selank
Thr-Lys-Pro-Arg-Pro-Gly-Pro (7 AA) Recommended Reconstitution Diluent:
Bacteriostatic Water or Sterile Saline
Alternative: Sterile Water for Injection Degradation Timeline:
Reconstituted at 4°C (Refrigerated):30 days
Reconstituted at 22°C (Room Temp):7 days
Lyophilized Powder at -20°C:24 months
Freeze-Thaw Tolerance:Poor
Light / UV Sensitivity:High
Handling Protocol:C-terminal Pro-Gly-Pro sequence provides enzymatic stability against aminopeptidases, but aqueous solutions degrade if exposed to warm temperatures.
Tesamorelin
Trans-3-hexenoyl GHRH (1-44) amide Recommended Reconstitution Diluent:
Sterile Water for Injection (original FDA protocol) or Bacteriostatic Water
Alternative: Sterile Saline 0.9% Degradation Timeline:
Reconstituted at 4°C (Refrigerated):7 - 14 days (reconstituted with BAC) / 24 hours (with sterile water)
Reconstituted at 22°C (Room Temp):4 - 8 hours
Lyophilized Powder at -20°C:24 months
Freeze-Thaw Tolerance:Extremely Poor
Light / UV Sensitivity:High
Handling Protocol:High molecular weight 44-AA chain. Very fragile. FDA single-dose vials are meant for immediate use; BAC water extends stability up to 7-14 days at 4°C.
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